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Medesan C, Cianga P, Mummert M, Stanescu D, Ghetie V, Ward ES

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Therefore, DHODH/CoQH 2 and mitochondrial GPX4 constitute two major ferroptosis defense systems to eliminate cell damage or death caused by the accumulation of mitochondrial lipid peroxides, and preclinical studies have shown that targeting DHODH can promote ferroptosis[36]

Considering the abundance of Hb in RBCs (corresponding to 10 m M heme), the reaction of autoxidation of Hb is therefore the most abundant source of ROS in RBCs

Ketogenic diet aggravates colitis, impairs intestinal barrier and alters gut microbiota and metabolism in DSS-induced mice