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doi: 10.1007/s11596-018-1862-9

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11(3): 27-47 URL: DOI: Depression is a neuropsychiatric disorder that has in recent times become a leading cause of disability and a major contributor to global disease burden and suicide[1]

SIRT1 deacetylates and activates heat shock factor 1 (HSF1) affecting heat shock protein 70 (HSP70) transcription and the latter can decrease abnormal protein aggregation (Westerheide, 2013)