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This is another reason the 28-day rule exists

Hypotonia, impaired motor development and cognitive development, movement disorders (mainly dystonia), and parkinsonism/hypokinetic rigid syndrome (consisting of bradykinesia, extrapyramidal rigidity (cogwheel rigidity), rest tremor and/or postural instability) are the hallmarks of BH 4 Ds and should prompt clinicians to include BH 4 Ds in the differential diagnosis