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p53 is involved in the regulation of more than 500 target genes and thereby controls a broad range of cellular processes, including metabolic adaptation, DNA repair, cell cycle arrest, apoptosis, and senescence Because of its pro-apoptotic function, p53 is recognized as tumour suppressor, and is found mutated in more than half of all human cancers affecting a wide variety of tissues

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10.1111/j.1749-6632.2000.tb06181.x 12 BrownG