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The MTHFR enzyme is thermolabile (deactivated by heat) and its activity may be further reduced in individuals with polymorphisms as environmental temperatures rise due to global warming exacerbated by air pollution

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ALDH2 contributes to melatonin-induced protection against APP/PS1 mutation-prompted cardiac anomalies through cGAS-STING-TBK1-mediated regulation of mitophagy

The gut microbiome composition associates with bipolar disorder and illness severity

In some cases, this can even lead to the onset of preterm labor, which requires immediate medical attention and ongoing fetal monitoring