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Under conditions with overwhelming nitrosative stress, the signalling kinase pathway phosphoinositide-3-Kinases/v-Akt murine thymoma viral oncogene (PI3K/AKT) is involved in the activation of Nrf2 and the Nrf2-dependent genes [66]

Similarly, CD4 + Tregs inhibit the activation and proliferation of autoreactive T cells through direct contact or the secretion of inhibitory cytokines such as IL-10 and TGF-

2014;129:S1-45

Glutathione is sometimes used for skin brightening, but the evidence is more limited

Generally, they are used to reinforce vital energy, tonify the spleen and lung, generate fluid and nourish the blood, calm the mind and improve intelligence in TCM