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6.2 Oral delivery strategies for flavonoids Despite their diverse pharmacological activities, the systemic application of flavonoids remains constrained by limited aqueous solubility, low oral bioavailability, rapid metabolic clearance, and insufficient targeting to skin and immune tissues

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KEGG pathway analysis of downregulated (upper panel) and upregulated (lower panel) genes in Bmal1 -KO vs

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Naturally occurring glucocorticoids are part of the feedback mechanism the body utilizes to reduce immune activity (inflammation)