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doi: 10.1186/ar4354 18 KaruT

That if you have this kind of oxidative stress going on that is leading to mitochondrial shutdown, you know, one of the key symptoms on a subjective level as far as what a person would feel of this happening is of course fatigue

This metabolic pathway is often hijacked by oncogenic drivers such as RAS and MYC, which enhance CHKA expression to meet the demands of rapid proliferation and membrane biogenesis (Kortlever et al., 2017)