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Participants with renal impairment were excluded if they had previously undergone renal transplantation or had unstable renal function or acute exacerbation of renal disease within 14 days of baseline, as indicated by recent history or worsening of clinical or laboratory signs

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Shoulders on the main peak or unexpected peaks at 30-60% of the main peak retention time suggest truncated sequences (deletion products from failed couplings) that often retain partial activity and confound pharmacological interpretation

A substudy of the ENGAGE AF-TIMI 48 trial revealed that 2740 of the 14,071 patients who received either warfarin or the high-dose edoxaban regimen (HDER