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65 Traditional Chinese Medicine Targeting HIF-1 Several malignant tumors, such as colorectal cancer, develop functioning blood arteries to facilitate tumor growth and spread to other body parts

The above results indicated that the T-BPH rat model was successfully established, and the prostate of T-BPH rats showed accelerated proliferation activity, decreased apoptosis, shortened G0/G1 phase and down-regulated GPX3 expression, all of which could be reversed by TRO treatment

Comparison of RNAseq datasets To enable a meaningful comparison of datasets, we use a customized ranking factor (RF), defined as: This approach combines both the magnitude of gene expression change (log 2 fold change) and the statistical significance (adjusted P -value) into a single metric, providing a more robust measure of gene importance

Glycolysis produces less ATP (~ 2 per glucose) at a faster rate than OXPHOS and provides metabolic intermediates required for the biosynthesis of nucleotides, amino acids, and fatty acids [47]

A multivariable logistic regression analysis adjusted for sex, age and lifestyle factors showed that fast eating (hazard ratio (HR): 1.51, 95% confidence interval (CI): 1.24-1.83, p 240 days apart