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Description

S100A4 enhances protumor macrophage polarization by control of PPAR--dependent induction of fatty acid oxidation

During reperfusion, the ischemic tissues release pro-inflammatory cytokines, such as tumor necrosis factor-alpha (TNF- ), interleukin-1 (IL-1), and interleukin-6 (IL-6), which contribute to the recruitment of neutrophils, macrophages, and other immune cells to the site of injury (Pawluk et al., 2020