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Previous studies have shown that HOCl induces N -chlorination in lipids containing a head group amine, such as phosphatidylethanolamine (PE) (Carr et al., 1998

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Importantly, this study also demonstrated that the B12 reduction associated with metformin use is not transitory but persists and progresses over time and, in some patients, to levels at which replacement is recommended

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folate deficiency, which will impact negatively on the BH4 salvage pathway activity through the participation of DHFR [136,137]

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Kartalou, M

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