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Andres LM, Blong IW, Evans AC, Rumachik NG, Yamaguchi T, Pham ND, et al

Thus, these results suggest that pancreatic cancer cells carrying both KRAS and p53 mutations are vulnerable to BSO and DPI combinatory inhibition, and the cytotoxic effect of BSO and DPI was mainly triggered by a redox-mediated mechanism

subsequently showed that NADH and succinate could decrease the tocopheroxyl radical in mitochondria, therefore converting CoQ10 to its ubiquinol form [115]

Similarly, ERK (extracellular signal-regulated kinase) and its involvement in melanin synthesis via the ERK/CREB (cAMP response element binding protein) pathway demonstrate how kinases contribute not only to antioxidant defense but also to pigmentation regulation by upregulating MITF and TRP1 69,71

CB-839 has varied effects on the function of different types of T cells, thereby affecting the immune response