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402,403,404 By modulating PPAR/TRPC1/TRPC6 expression or inhibiting Notch3 signaling, sildenafil effectively mitigated PASMCs proliferation and HPVR, alleviating right ventricular pressure/hypertrophy

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Increases in the accumulation of reactive oxygen species are related to polymorphisms in antioxidant enzymes such as glutathione peroxidases and glutathione S-transferases, which are linked to an increased risk of vascular disease

We first studied hyperpolarized [1- 13 C]dehydroascorbate in the normal rat brain, demonstrating its robust conversion to [1- 13 C]vitamin C, consistent with rapid transport of the oxidized form across the blood-brain barrier

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