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Hoffmann-La Roche, Janssen, Merck Serono, Merck Sharp and Dohme, Novartis, Pfizer, Regeneron and Takeda

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Once TMAO formation/concentration is elevated, it may increase the risks of atherosclerosis for healthy individuals ( TMAO and HF HF is defined as a group of syndromes caused by structural or functional damage that results in impaired ventricular filling or cardiac output, and which involves multi-organ and systemic neurohumoral dysfunction (89)