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Upon activation, caspase-1 enzymatically processes the precursor pro-interleukin-1 (pro-IL-1) into its biologically active form, mature IL-1, which is then secreted into the extracellular milieu, triggering a robust inflammatory response ( Moreover, MSU triggers the release of pro-inflammatory cytokines, such as interleukin-6 (IL-6), through the NF-B and Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling cascades, consequently amplifying the infiltration of inflammatory cells ( Figure 1 )

Design of yeast-secreted albumin derivatives for human therapy: Biological and antiviral properties of a serum albumin-CD4 genetic conjugate

Some recent work aimed to develop tamoxifen analogues that can bypass CYP2D6 metabolism and use the esterase enzymes to produce the active metabolites to ensure equal clinical outcomes for all patients [66,67,68]

doi: 10.1016/j.clim.2023.109655 21 RatajczakWAtkinsonSDKellyC

10.1111/imr.12910 Immunol