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A study employing high-resolution immunocytochemistry at both light and electron microscopic levels in rodents has demonstrated that neurons efficiently uptake lactate via monocarboxylate transporter 2 (MCT2), a high-affinity transporter localized at postsynaptic densities to facilitate lactate import from astrocyte-released sources (Bergersen, 2007) and subsequently convert it to pyruvate via lactate dehydrogenase isotype 1

The cells were treated with either 0.1% DMSO, 10 M cyclosporine A, 1 M thapsigargin or 100 M puromycin for 15 to 60 minutes in complete medium

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of 0.6 for 1,194 C -atoms of two complexes

Based on these differences, hepatocytes are categorized into three zones: periportal hepatocytes (Zone 1), midlobular hepatocytes (Zone 2), and pericentral venous hepatocytes (Zone 3)