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These effects were associated with lowered levels of pro-inflammatory cytokines such as IL-17 and IL-23, reduced oxidative stress markers like malondialdehyde (MDA) and reactive oxygen species (ROS), and suppression of signaling pathways including PI3K and STAT3

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Semisolid wet solgel silica/hydroxypropyl methyl cellulose formulation for slow release of Serpin B3 promotes wound healing in vivo

It also stimulates the expression of genes encoding BDNF, enkephalin, and anti-inflammatory interleukins

The pLKO.1-scramble vector (#1864, Addgene) was used as a negative control vector and contained a scrambled shRNA (shC)