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After consideration of public comments we received, we are finalizing without modification our proposal to calculate the target PCR based on our longstanding target PCR calculation methodology described in this final rule with comment and then apply the 1.0 percentage point reduction as required by section 16002(b) of the 21st Century Cures Act

Multiple signaling mechanisms that boost antioxidative responses make multivitamin supplementation a potentially effective treatment for neurodegenerative diseases [21,22,23]

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