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Ferroptosis is defined by excessive intracellular iron accumulation due to metabolic imbalance, where Fe 2+ generates a large amount of hydroxyl radicals (OH) through the Fenton reaction (Figure 2)

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Upon MT1 binding, the receptor is thought to activate adenylyl cyclase, converting ATP to cyclic adenosine monophosphate (cAMP)

Ripasudil was first approved in Japan in 2014 and has undergone several clinical trials led by Tanihara et al

Larger LDs tend to contain PLs with unsaturated fatty acyl chains (e.g., dioleoylphosphatidylcholine), which increase monolayer fluidity and facilitate LD expansion