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Orforglipron is another drug in the pipeline, demonstrating activity only as a GLP-1 agonist

References Vukojevic J, Milavi M, Perovi D, Ili S, ili AZ, uran N, trbe S, Zorii Z, Filipi I, Brei P, Seiverth S, Sikiri P

The publication was co-financed by the state budget under the program of the Minister of Education, and Science called Science for the Society II, project number NdS-II/SN/0270/2023/01, amount of funding 56,952 PLN total value of the project 1,956,000 PLN

Evidence implicating disruption in intestinal barrier functions in the development of many systemic diseases, ranging from non-alcoholic steatohepatitis to autism, or systemic complications of intestinal disorders has increased rapidly in recent years, raising the possibility of the intestinal barrier as a potential target for therapeutic intervention to alter the course and mitigate the complications associated with these diseases