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Recent Phase I/II trials are recruiting to test for molecularly matched targeted therapies (APG101, Alectinib, Idasanutlin, Atezolizumab, Vismodegib, Temsirolimus and Palbociclib) in combination with radiotherapy in patients with newly diagnosed glioblastoma without MGMT promoter methylation (NCT03158389)

This limitation highlights the need to pair such therapies with agents that promote epithelial repair and balanced mucin production such as cystic fibrosis transmembrane regulator modulators, growth factors or emerging mucosal regenerators to fully restore airway defence and function 251,252

doi: 10.1002/art.42447 144 JutabhaPKumarVAnzaiNRicePJLightnerJWEndouHet al

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