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While the astrocytes are predominantly involved in maintaining the neural tissues homeostasis, the failure of the astroglial defense system facilitates the generation of impaired synaptic transmission, neurodegeneration, and death of neurons (Verkhratsky et al., 2019a,b)

Additionally, it plays a key role in influencing the hypothalamus and pituitary gland, regions of the brain central to sleep and hormonal balance, further enhancing its impact on the sleep cycle

Pyruvate released by astrocytes protects neurons from copper-catalyzed cysteine neurotoxicity

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