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However, its universal effectiveness lacks comprehensive scientific validation

There are no other absolute contraindications reported for hydroxocobalamin use in deficiency states, but caution is advised in individuals with conditions such as early Lebers optic neuropathy (a rare hereditary optic atrophy) due to the theoretical risk of worsening vision

Therapeutic doses of vitamin D can differ based on the same variables, but 50,000 IU (1,250 mcg) is a common amount according to the journal Nutrients