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They exhibit multi-target and multi-mechanism anti-cancer actions, including direct cytotoxicity against tumor cells, suppression of tumor growth and metastasis, immunomodulation, and enhancement of chemotherapy effectiveness, along with reduced treatment-related side effects

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Endothelial-dependent relaxation, mediated by nitric oxide (NO), was evaluated in vitro in pulmonary artery rings exposed to different concentrations of acetylcholine and ADP

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