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2024;12(6):e5860

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Finally, it will be important to study serial samples from patients throughout their clinical course to evaluate the serum metabolome as a function of clinical status (e.g., stage of infection, on or off a ventilator, receiving hemodialysis or not) and in response to various therapies (e.g., treatment with IL-6 receptor inhibitors)

Enrica Papa (School of Architecture and Cities, University of Westminster), Dr Sabina Cioboata (School of Architecture and Cities, University of Westminster) T_04 GOVERNANCE (A): Metropolitan and regional planning A1-11 (YTU Davutpasa Campus) A1-11 YTU Davutpasa Campus Convener: Eva Purkarthofer (Aalto University) 639 State-local political interactions in governing complex regions: empirical evidence from cross-jurisdictional metropolitan regions Yangtze River Delta in China and Rhein-Neckar in Germany With enhanced inter-city connectivity and extended urbanization, cities were expanding beyond their traditional city limits to become global city-regions through metropolisation (Scott, 2001)

Given that efficacy is related to trough levels, more frequent dosing may be sensible in patients with augmented renal clearance (e.g., 1 gram IV q8hrs rather than 1.5 grams q12hrs)