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Because they are more agile, they can quickly neutralize reactive oxygen species (ROS) and halt the destructive process of lipid peroxidation, which is a major driver of cellular aging and chronic disease

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Reduced HIF-1 availability may limit HIF- signaling even under hypoxic conditions, whereas increased or stabilized HIF-1 can amplify hypoxia-responsive transcriptional programs, contributing to tumor progression, therapy resistance, and immune evasion (59)

Paraptosis plays a crucial role in cell death, in which cytoplasmic vacuolization may result as an alternative to overcoming apoptosis resistance