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In fact, research shows that people with this gene mutation still process this nutrient, although the amount is about 16% lower

While CB-839 inhibited the proliferation of patient-derived glioma cell lines, it did not affect cell viability (103).In NSCLC, KEAP1 mutant NSCLC cell lines exhibit a dependence on Gln, and the GLS inhibitor CB-839 can inhibit Gln metabolism to exert anti-tumor effects (104)

The samples were then boiled at 99 C for 10 min and finally subjected to WB analysis

Impairment of glutathione function in the brain is linked to loss of neurons during aging and to neurological diseases including Parkinson's disease and Alzheimer's disease

Cell 180 , 585600 e519 (2020)