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This article addresses critical gaps in ferroptosis research by: (1) Systematically analyzing shared mechanisms across neurodegenerative diseases, acute brain injury, and neuroimmune disorders, revealing ferroptosis as a molecular bridge linking diverse pathologies

Inhibitor for JNK (JNKi) and ASK1 (ASKi) were from Tocris Bioscience (Ellisville, MO, USA), Tamoxifen (TAM) and Microcystin-LR were from Cayman Chemical Co (Ann Arbor, MI, USA), Matrigel was from BD Biosciences (Mississauga, ON, Canada) and peanut oil was from Sobeys (Edmonton, AB, Canada)

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A recent study confirmed that among 1201 patients with NSCLC, more than 60% of initial responders to PD-L1 blockade relapse, and adaptive resistance to PD-L1 blockade in NSCLC is associated with ongoing but altered inflammation and IFN signaling [83]

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