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Disclosure of interest: No conflict of interest E-Posters - NOVEL TARGET/ EXPERIMENTAL FIDINGS TO CLINICAL TRANSLATION 06.00 - NOVEL TARGET/ EXPERIMENTAL FIDINGS TO CLINICAL TRANSLATION - 06.02 - GENETICS, OMICS AND BIOMARKERS P2577 - ESOC25-782 LARGE ARTERY ATHEROSCLEROTIC STROKE RELATED SNP VARIANTS ASSOCIATED WITH STROKE RISK FACTORS AND MECHANISMS IN SYMPTOMATIC INTRACRANIAL ATHEROSCLEROSIS Yue Gu 1 , Yifu Wang 2 , Qiaoshu Wang 2 , Xinyi Leng 1 1 Department of Medicine and Therapeutics, the Chinese University of Hong Kong, Hong Kong, Hong Kong, 2 Department of Neurology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China Background and Aims: Previous studies have identified numerous risk loci for large artery atherosclerotic stroke (LAAS)

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Why Belly Fat May Respond Differently Than Other Body Parts to Injections Belly fat creates unique challenges compared to other areas

The success of this approach in modulating both energy metabolism and epigenetic regulation suggests that other metabolic nodes may offer similar opportunities for dual-pathway intervention