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Cholecystectomy promotes the development of colorectal cancer by the alternation of bile acid metabolism and the gut microbiota

Intestinal disorders and the loss of gut microbiota diversity impair the integrity of the intestinal barrier and can allow harmful microbial products, such as lipopolysaccharides, to enter the bloodstream, leading to systemic inflammation and metabolic disorders, which can weaken muscle function and reduce muscle mass (91) (Figure 3)

The human body normally has levels of 50-60 mol/L of total carnitine and 40-50 mol of free carnitine

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It may occur either as a predictable event when an individual is exposed to toxic doses of some drugs or as an unpredictable event with many commonly used medications ( In this review, we systematically summarized the recent advances in natural products with potential anti-DILI effects (including flavonoids, phenylpropanoids, terpenoids, and glycosides) over the past 5 years, and the mechanisms of hepatoprotective effects were also discussed