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C.SchrauwenP.KalsbeekA

New basic and clinical research is clarifying the mechanistic relevance and therapeutic feasibility of multiple targets within the glutamate system for novel drug discovery, including NMDA and AMPA (-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid) receptors, metabotropic glutamate receptors, and other key regulatory proteins such as glycine transporter 1 and excitatory amino acid transporters

Both glycolytic substrate level phosphorylation as well as mitochondrial oxidative phosphoylation contribute to ATP regeneration from ADP and both processes have reserve capacity to compensate at least in part for an impairment of the other process

Especially in the past half century, global warming has driven drier environment and higher water evaporation, as a result, leading to mucus thinning, epithelial compression and subsequent inflammation 289

A common DIO2 haplotype composed of the minor C-allele of SNP rs225014 and the common C-allele of SNP rs12885300 was significantly associated with advanced hip OA, as indicated by a higher odds ratio 101,102,103