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LPS passes through the lining into the bloodstream, leading to chronic low-grade inflammation, which not only impacts metabolic health and weakens the immune system, but also creates a gut environment that may not be supportive of microbial diversity ( Bilophila wadsworthia , whose metabolic products (e.g., hydrogen sulfide) are known to inflame intestinal tissue and contribute to inflammatory bowel disease ( Blautia and Faecalibacterium prausnitzii , which is an anti-inflammatory agent ( Bilophila ), while reducing populations of bile-sensitive beneficial bacteria, disrupting the gut microbial balance ( Bifidobacterium, Lactobacillus, Lachnospira, and Roseburia ( Regarding a protein-rich diet, depending on the source of protein, timing of consumption, and whether there is adequate intake of carbohydrates and fiber, the effects on microbial diversity vary ( Alistipes , Bilophila , and Bacteroides increased with a protein-rich diet, along with decreased levels of Roseburia , Eubacterium rectale , and Ruminococcus bromii

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Yoo HC, Yu YC, Sung Y, Han JM

L-Carnitine is a nutrient that plays an important role in energy metabolism