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Sex as a biological variable It is worth noting that although CYP1A2 activity is higher in men than in women, no significant gender differences in caffeine metabolism have been observed when assessed using urinary metabolite patterns or metabolite ratios [116]

2.2.2.Glutathione (GSH) is synthesized in cells through a two-step enzymatic reaction facilitated by the enzyme Glutathione synthetase, which is often abbreviated as GshF