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A published article confirmed that no increase in SOD2 expression was detected in primary neurons or astrocytes, while the mRNA and protein levels of SOD2 were significantly increased in rat primary microglia treated with LPS, poly (I:C), peptidoglycan, or CpG oligodeoxynucleotides, suggesting that SOD2 was specifically induced in microglia under inflammatory conditions [59]

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The LSD1 inhibitor RN-1 induces fetal hemoglobin synthesis and reduces disease pathology in sickle cell mice