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The 2024 Cureus systematic review by Jaiswal and Jawade reaches the same conclusions across more than 60 cited studies: the wound-healing cascade and the delivery enhancement are two separable mechanisms, and which one dominates depends on needle depth, needle architecture, and how the serum is introduced [1]

Here we have outlined potential strategies that target crosstalks between epigenome and metabolome that might be exploited to selectively inhibit tumorigenesis

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QUE pre-treatment of Tca-8113 and SCC-15 OSCC lines enhanced CIS cytotoxicity by inhibiting AKT and IKK phosphorylation, the NF-B pathway, and expression of the anti-apoptotic protein xIAP (61)