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You may benefit from B12 shots if you: Have low or borderline B12 levels Follow a vegetarian or vegan diet Have had gastric bypass or other gastrointestinal surgeries Suffer from digestive disorders like IBS, Crohns, or celiac disease Experience chronic fatigue or frequent brain fog Have been diagnosed with depression, especially if treatment-resistant Are an older adult (as absorption decreases with age) Take certain medications (like metformin or proton pump inhibitors) that affect B12 absorption Even if you dont fall into one of these categories, a B12 injection may still offer benefits if youve been feeling mentally sluggish or emotionally drained