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Physiol Rev 71(1):129153

The N-terminus was fused to three surface-displaying sequences: Lp_1452, Lp_1568, and Lp_3014 natively from Lp 51 (Supplementary Fig

Flavanones lack a double bond between C2 and C3, and this makes them chiral at the C2 position

GPs can prescribe B12 injections following appropriate investigation, which should include: Full blood count to identify macrocytic anaemia Serum B12 and folate levels to confirm deficiency (using laboratory-specific reference ranges) Methylmalonic acid and/or homocysteine when B12 results are borderline Intrinsic factor antibodies if pernicious anaemia is suspected Additional tests depending on clinical presentation (e.g., thyroid function, coeliac serology) When both B12 and folate deficiency are present, B12 should be replaced before folate to avoid precipitating subacute combined degeneration of the spinal cord

Methods Enzymol 528:325