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For instance, research indicating hypomethylation of genes like DKK1, LGR6, and PRICKLE1 in patients with AS has demonstrated encouraging diagnostic potential, evidenced by moderate area under the curve values in ROC analyses ( 3.4 Inherent biological and methodological challenges In addition to technical and financial obstacles, the clinical application of DNA methylation biomarkers in AS faces considerable biological and methodological challenges.Cellular heterogeneity is a major biological concern

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At the same time, its antioxidant and anti-inflammatory properties help limit oxidative stress and local inflammation, two factors that can slow down the healing process

Tomatidine suppresses osteoclastogenesis and mitigates estrogen deficiency-induced bone mass loss by modulating TRAF6-mediated signaling

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