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Setria L-Glutathione

Indications: FDA : Topical anesthesia of the upper respiratory tract (due to its combined vasoconstrictor & local anesthetic properties) Off Label : Use in Emergency Department as one ingredient in a topical anesthetic solution called TAC (containing: Tetracaine, Adrenaline & Cocaine) that is applied to a wound prior to cleaning & suturing Contraindications: Hypersensitivity to ester anesthetics Side Effects: Acute signs of systemic toxicity include can include multiple signs of both CV & CNS stimulation: tachycardia hypertension hyperthermia mydriasis seizures cardiac arrhythmias (multiple contributing variables: Na & K channel block, possible coronary vasoconstriction) Acute effects associated with cocaine abuse

Its also the only vetted program offering a structured microdosing option lower-dose protocols designed for gentler titration, which matters for medication-sensitive patients

One mouse in vehicle group had supraphysiological glucagon levels outside the assay range and was omitted from analysis

doi: 10.1097/FPC.0b013e328337f992