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This is relevant, as platelets are the first cells that arrive at a site of injury to release various factors that initiate the repair process

Also, p62 recruited to the damaged mitochondria ubiquitinates Mcl-1, leading to its degradation and activation of apoptosis [305]

Cellular cisplatin accumulation is mainly determined by copper transporter-1, responsible for cisplatin uptake 6,7 and ABCB1 , encoding multidrug-resistant protein 1 (MDR1) involved in increasing platinum-drug export 8,9

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Common examples include: These are designed to mimic or enhance the bodys own signaling molecules while extending their activity through modifications like PEGylation , fatty acid chains , or amino acid substitutions