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Daphnetin alleviates allergic airway inflammation by inhibiting T-cell activation and subsequent JAK/STAT6 signaling

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Digital images were captured using an Olympus BX41 microscope and Olympus Color View I camera or using the Hamamatsu NDP slide scanner (Hamamatsu Nanozoomer 2.0HT)

While the formation of 5-(3,4-dihydroxyphenyl)--valerolactone from (+)-catechin by intestinal bacteria has already been described by Das ( Eggerthelia lenta and Adlercreutzia equolifaciens species, followed by activities of Flavonifractor plautii strains ( 2 , with monomers being linked via a single interflavan bond, are more readily cleaved compared to A-type procyanidins with two interflavan bonds ( After intake of Pycnogenol , the microbial metabolites 5-(3,4-dihydroxyphenyl)--valerolactone (previously also named -(3,4-dihydroxyphenyl)--valerolactone or M1) and 5-(3- methoxy-,4-hydroxyphenyl)--valerolactone (previously also called -(3- methoxy-,4-hydroxyphenyl)--valerolactone or M2) were identified in urine samples of a volunteer as phase II conjugates (