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doi: 10.1073/pnas.051627098

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Blocking ALDH causes an accumulation of acetaldehyde in the body resulting in the very unpleasant mal rouge syndrome

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On the other hand, evaluation of the corticosteroid hormone cortisol is mandatory before starting thyroid hormone replacement, as it otherwise may trigger a steroid crisis in patients with untreated adrenal insufficiency by accelerating the metabolism of cortisol and increasing the metabolic rate