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What we know Several aspects of immune function decline with increasing age and older individuals are more susceptible to infection and have a poor response to vaccination

They are also frequently discovered in bigger resistance islands, which frequently include the virulence genes fimH , fyuA , irp2, and sitA as well as the chromate-resistance gene chrA, the aminoglycoside genes aac(3)-IIa , aac(6)-Ib-cr , and aadA2 , and the gene bla CTX-M

Phosphorylated STAT1 enters the nucleus and directly inhibits the cystine/glutamate antiporter system Xc= (composed of SLC7A11 and SLC3A2), resulting in a 60%-80% reduction in GSH synthesis and a 3-5-fold increase in lipid peroxidation levels due to impaired GPX4 activity (219, 221)

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Chen J, Zhang W, Guo Q, Yu W, Zhang Y, He B