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If I understand rightly you haven't an absorption problem.So once on supplements or a richer B12 diet you can store and utilise b12 from your liver

There is supporting evidence reporting adverse effects from long-term rhIGF-1 treatment including neoplastic formation, cataract and renal hypertrophy, all of which seem to be the most severe effects observed and are usually rare [123, 282284]

It acts as a signaling molecule, communicating the state of the mitochondria to the rest of the cell

This information is invaluable for your healthcare provider in determining whether symptoms are genuinely related to B12 supplementation or reflect an independent condition requiring separate investigation

For adipogenic differentiation, Oil Red O staining demonstrated the presence of lipid vacuoles within the cytoplasm of hGMSCs, indicative of adipocyte formation