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1996;276:1957 ral tube defects (defects of the spine) and cleft 63) lip and palate.19,22 High-dose supplements of 4 1 The Basic Principles of Micronutrition vitamin B6 and zinc can enhance T cell activity 150200 mg/day reduces the risk of coronary and may increase resistance to infection.21 heart disease by 40% in adult men and Vitamin E is another micronutrient that de- women.22 An intake of 200400 mg/day can velops new, beneficial actions at higher doses (Fig 1.1)

High concentrations of aspartate in lung interstitial fluid activate the ionotropic N-methyl-D-aspartate receptor and promote CREB-dependent expression of deoxyhypusine hydroxylase, which triggers a translational program centered on TGF- signaling, enhancing collagen synthesis in DTCs and facilitating their colonization and survival [204]