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J Exp Bot 59(8):22672276

Studies indicate that IF can lead to weight loss results comparable to those achieved through continuous calorie restriction

However, the considerable overlap of functions between these receptors is exemplified in breast cancer where it has been suggested that inhibition of both IGF-1R and IR may be required for effective antitumour response ( As well as the hypothalamic pituitary GH axis, IGF-1 secretion is controlled by autocrine/paracrine signals in peripheral tissues