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Contrary to claudin-1, which in normal colonic epithelial cells is expressed to a minimum (even though it is highly increased in colon cancer tissue and cells 65 ), the claudin-7 protein is highly expressed in the colonic epithelium

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In this study, we designed two novel targeting peptide motifs to enhance the interaction between cosmetic peptides and the cell surface, thereby improving their performance for skin health

10.1016/j.ccell.2014.09.003 312

This process depends heavily on nitric oxide (NO), a crucial signalling molecule that relaxes smooth muscle in penile blood vessels