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Simultaneously, Carb-restricted ketosis switched on the Sirt1-Nrf2 relay in sleep-loss mouse hippocampal tissue

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In the context of prolonged systemic administration, NMDA receptor antagonists, such as memantine and MK-801 (also known as dizocilpine), induce anorexia and weight loss in rodents 9,10,11

As summarized in Table 4, preclinical and clinical studies support cardioprotective effects of metformin across diverse cardiac conditions, but large, rigorously designed trials are needed to define its role beyond metabolic indications

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