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Urate induced dysregulation of immune cells potentially spurs the onset of HUA and the consequent complications, besides bolstering chronic inflammation

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Recent studies demonstrated that restraint stress produces antinociception which is relevant to numerous painful pathologies, such as fibromyalgia (FM), characterized by diffuse muscular pain (hyperalgesia) and/or tenderness (allodynia)

The 20202025 Dietary Guidelines for Americans emphasize personalized nutrition and increased awareness of nutrient adequacy, fueling consumer interest in supplementation

Acknowledgments Parts of the figures were generated with the help of BioRender